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“Following the ascendancy of the conservative Sunni Caliph al-Mutawakkil, whom Syed Ameer Ali describes as a 'cruel drunken sot in league with the qazis and mullahs,' the physical extermination of Mu'tazilites, together with Shias, began in earnest. They were removed from all governmental positions, accused of heresy, subjected to torture, and summarily executed. Scholars and scientists, most of whom subscribed to rationalist beliefs, fled Baghdad for other parts of the Islamic world. Thus ended the most serious attempt to combine reason with revelation in Islam. Apart from various isolated efforts by individua119th century Muslim reformers, the separation between the religious and secular has been complete in Islam ever since.”