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“The real heroes anyway aren't the people doing things; the real heroes
are the people NOTICING things, paying attention. The guy who invented the smallpox vaccine didn't actually invent anything. He just noticed that people with cowpox didn't get smallpox.”
― John Green, The Fault in Our Stars

“At present, intelligent people do not have their children vaccinated, nor does the law now compel them to. The result is not, as the Jennerians prophesied, the extermination of the human race by smallpox; on the contrary, more people are now killed by vaccination than by smallpox.”
― George Bernard Shaw

“Ask the Aztecs and the Incas whether or not they would have liked to have access to vaccines. Oh, wait, you can't. They're dead. Vaccination is one of the best things that has happened to civilization. Empires toppled like sandcastles in the wake of diseases we do not give a second thought to today. If taking a moment to elaborate on that point will make this book unpopular with a large group of antivaxxers, that’s okay. This feels like a good hill to die on. It’s surely a better one than the Incas got.”
― Jennifer Wright, Get Well Soon: History's Worst Plagues and the Heroes Who Fought Them

“One of the medical profession's greatest boasts is that it eradicated smallpox through the use of the smallpox vaccine. I myself believed this claim for many years. But it simply isn't true!”
― Dr. Vernon Coleman

“I attained a triumph so complete that it is now rare to meet an American with marks of small pox on his face... Benefits are valuable according to their duration and extent... but the benign remedy Vaccination saves millions of lives every century, like the [gift] of the sun, universal and everlasting.

[Remark made near the end of his life]”
― Benjamin Waterhouse

“Vaccine trials are done on healthy individuals. Let’s say they measure the safe rate of replication for a healthy child and then use that same vaccine on a child with a compromised immune system. What appears to happen at times, is that some children have such a severely compromised immune systems that it causes the virus to replicate out of control[68]. Vaccines that are manufactured this way are the rotavirus, measles-mumps-rubella (MMR), smallpox and chickenpox vaccines.”
― James Morcan, Vaccine Science Revisited: Are Childhood Immunizations As Safe As Claimed?

“They were still talking about polio, now by recalling its frightening precursors. His grandmother was remembering when whooping cough victims were required to wear armbands and how, before a vaccine was developed, the most dreaded disease in the city was diphtheria. She remembered getting one of the first smallpox vaccinations. The site of the injection had become seriously infected, and she had a large, uneven circle of scarred flesh on her upper right arm as a result.”
― Philip Roth, Nemesis

“Or look at the status of women, about which finally the planet is coming to its senses in our own time. Or even things like smallpox and other disfiguring and fatal diseases, diseases of children, that were once thought to be an inevitable, God-given part of life. The clergy argued, and some still do, that those diseases were sent by God as a scourge for mankind. Now there are no more cases of smallpox on the planet. For a few tens of millions of dollars and the efforts of physicians from a hundred countries, coordinated by the World Health Organization, smallpox has been removed from the planet Earth.”
― Carl Sagan, The Varieties of Scientific Experience: A Personal View of the Search for God

“On April 30 Lucy cheerfully reported that, after three days' illness, she was on the mend. Although she had no mirror, she could feel twenty pockmarks on her face. 'I am almost glad you do not see it.," she wrote, "I don't believe I should get one kiss and yet the doctor tells me it is very becoming.”
― Nancy Rubin Stuart, Defiant Brides: The Untold Story of Two Revolutionary-Era Women and the Radical Men They Married

“They were as good and as strong as Rome. Historical fluke the Spanish ever managed to get the better of them.â€�

‘How did they?� I said, wanting suddenly and badly to know.

‘Smallpox,â€� he said. ‘It wasn’t strategy or anything like that. The Spanish brought smallpox with them when they landed in Mexico. It arrived in Peru before they did. And the Inca had built a wonderful, efficient road system for it to travel on. The royal family was obliterated in five years, the administration of the empire collapsed, and Pizarro took the whole thing with five thousand men. One of the most ridiculous confluences of bad luck in history.”
― Natasha Pulley

“The word 'vaccination' comes from vacca, the Latin word for 'cow'. This is a poignant recapitulation of the history of vaccines. The first vaccine properly so called had, as its active ingredient, the cowpox virus, a close relative of smallpox that however was much less likely to cause severe, disfiguring or lethal disease. Edward Jenner observed that milkmaids, who were often exposed to cowpox, suffered a relatively mild disease, but would be immune to the much more serious smallpox.

In an experiment that would unlikely pass muster in the modern world, he infected James Phipps, then an 8-year-old, with cowpox. He suffered a mild and transient illness, but when he was later exposed to scabs from a smallpox patient, he proved immune.

Unlike the earlier practice of variolation, which has been practised in late Song dynasty China that sought to induce the cutaneous form of smallpox, variola minor, to protect against the more severe forms of smallpox (variola major), Jenner's vaccination used a less pathogenic virus.
He relied on what would later be called 'antigenic similarity', but which was at the time hardly understood.”
― Chris von Csefalvay, Computational Modeling of Infectious Disease

“Vaccination has made smallpox extinct in the wild, as well as rinderpest, a relative of measles that affects cattle and buffalo, among others. Poliomyelitis, which has in its heyday killed and maimed millions of children and adults alike, is close to eradication, with fewer than 200 wild-type cases documented in 2020. Vaccines are some of the most effective public health interventions against infectious disease.”
― Chris von Csefalvay, Computational Modeling of Infectious Disease

“Up to 95 percent of the original Native American population, estimated at roughly twenty million people, disappeared after the invasion of European colonizers. While there was direct violence toward Native Americans, many of these deaths can be attributed to the introduction of smallpox. Smallpox is a virus that is spread when one comes into contact with infected bodily fluids or contaminated objects such as clothing or blankets. The virus then finds its way into a person's lymphatic system. Within days of infection, large, painful pustules begin to erupt over the victim's skin.

In school curriculums, this has often been taught as an unfortunate tragedy, an accidental side effect of trade, and therefore a reason to claim that the Europeans did not commit genocide. However, in recent years, many historians have recognized that the spreading of smallpox was an early form of biological warfare, one which was understood and used without mercy from at least the mid-1700s. Noted conversations among army officials include letters discussing the idea of "sending the Small Pox among those disaffected tribes" and using "every stratagem to reduce them." Another official, Henry Bouquet, wrote a letter that told his subordinates to "try to Innoculate [sic] the Indians, by means of Blankets, as well as to Try Every other Method, that can serve to Extirpate this Execrable Race." They followed through on their plan, giving two blankets and a handkerchief from a Smallpox Hospital alongside other gifts to seal an agreement of friendship between the local Native tribes and the men at Fort Pitt, located in what is now western Pennsylvania.”
― Leah Myers, Thinning Blood: A Memoir of Family, Myth, and Identity

“Mitty imagined emergency technicians seeing a rash, whipping out their handbooks, checking smallpox in the index. And then the instructions: Give up, you're dead.”
― Caroline B. Cooney, Code Orange